Encapsulation of N-Nitroso-melatonin with Poly(lactide-co-glycolide)
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چکیده
منابع مشابه
Polylactide-co-glycolide nanoparticles for controlled delivery of anticancer agents
The effectiveness of anticancer agents may be hindered by low solubility in water, poor permeability, and high efflux from cells. Nanomaterials have been used to enable drug delivery with lower toxicity to healthy cells and enhanced drug delivery to tumor cells. Different nanoparticles have been developed using different polymers with or without surface modification to target tumor cells both p...
متن کاملPolylactide-co-glycolide fiber-reinforced calcium phosphate bone cement.
OBJECTIVE To compare the strength of polylactide-co-glycolide fiber-reinforced calcium phosphate bone cement (FRC) with nonreinforced calcium phosphate bone cement (NRC) subjected to simulated dural pulsations in defects larger than 25 cm(2). METHODS Seven NRC and 7 FRC specimens were set in both medium (37.5 cm(2)) and large (50.0 cm(2)) model skull defects while subjected to simulated dural...
متن کاملEncapsulation of Naja –Naja Oxiana Snake venom into Poly (lactide-co-glycolide) microspheres
One small-scale double emulsion technique for incorporation of Naja- Naja oxiana venom into Poly (lactide-co-glycolide) (PLGA) microspheres were developed and optimized. The effects of high speed homogenization on the double emulsion stability, microsphere size, entrapment efficiency and In vitro release of venom were studied. A stable double emulsion was verified by homogenization method. Slow...
متن کاملEffect of Formulation Variables on Preparation of Celecoxib Loaded Polylactide-Co-Glycolide Nanoparticles
Polymer based nanoparticle formulations have been shown to increase drug bioavailability and/or reduce drug adverse effects. Nonsteroidal anti-inflammatory drugs (e.g. celecoxib) reduce prostaglandin synthesis and cause side effects such as gastrointestinal and renal complications. The aim of this study was to formulate celecoxib entrapped poly lactide-co-glycolide based nanoparticles through a...
متن کاملPreparation of polylactide-co-glycolide nanoparticles incorporating celecoxib and their antitumor activity against brain tumor cells
BACKGROUND Celecoxib, a cyclo-oxygenase (COX)-2 inhibitor, has been reported to mediate growth inhibitory effects and to induce apoptosis in various cancer cell lines. In this study, we examined the potential effects of celecoxib on glioma cell proliferation, migration, and inhibition of COX-2 expression in vitro. METHODS Celecoxib was incorporated into poly DL-lactide-co-glycolide (PLGA) nan...
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ژورنال
عنوان ژورنال: Journal of Biotechnology & Biomaterials
سال: 2017
ISSN: 2155-952X
DOI: 10.4172/2155-952x.1000258